Chaga mushroom extract suppresses oral cancer

Chaga mushrooms (Inonotus obliquus) have been widely studied for their anti-tumor effects on many types of cancers (lung, liver, breast, colorectal). A recent study confirms Chaga mushroom extracts suppress oral cancer as well.

The study, supported by the National Research Foundation, suggests Chaga mushroom extracts are a promising natural supplement for the treatment of oral cancer. While the exact mechanism requires more research, the study indicates Chaga mushroom extract slows oral cancer cell growth by suppressing the cancer cell’s energy metabolism.

Several studies have shown the antitumor effects of Chaga mushrooms against various cancers, including lung adenocarcinoma, breast cancer, liver carcinoma, and colorectal cancer6,7,10,31. Chaga mushroom extract inhibits the growth of breast cancer cells by inducing autophagy processes6. Chaga mushroom constituents exhibit cytotoxic and proapoptotic activities in human lung cancer cells7. In addition, Chaga mushroom-derived ergosterol peroxide suppresses proliferation of colorectal cancer cells through down-regulation of β-catenin signaling10. Similarly, we demonstrated that Chaga mushroom extract decreases the proliferation of oral cancer cells by modulating cancer energy metabolism and autophagy. Furthermore, we have shown the anti-tumor effect of this extract in oral cancer cells through regulation of several cell signal pathways, including AMPK, STAT3, p38 MAPK, and NF-κB. This study, for the first time, found that Chaga mushroom extract suppresses oral cancer cell progression by inhibiting glycolysis and mitochondrial membrane potential.

Mature mushrooms vs mycelium: A 2024 up-dated summary of scientific findings outlines Chaga’s notable anticancer, antioxidant, anti-diabetic, anti-inflammatory, antimicrobial, and immunomodulating properties. The summary suggests extracted compounds from fully mature Chaga mushrooms have more direct impact on cancer than compounds from Chaga mycelium.

While polysaccharides from Chaga mycelium work by triggering the immune system, those from Chaga sclerotium directly block protein synthesis in malignant cells. These extracts and extracted compounds have shown to be non-toxic and have been used as possible cancer-preventive and chemotherapy substitutes. Endopolysaccharides from the mycelium operate indirectly by stimulating the immune system, whereas heteropolysaccharides and homoglucans from the sterile conk have direct anticancer effects [92].

How to consume: Chaga mushrooms don’t look like most mushrooms. Mature Chaga mushrooms are sclerotium fungi that infect birch trees in a symbiotic relationship that forms large woody conks. While you can consume these with some effort, the best way to tap into Chaga mushroom’s nutritive and medicinal value is to use an extract like those used in scientific studies.

The Health Benefits of Lion’s Mane Mushrooms!

A wonderful article from the Cleveland Clinic outlines five health benefits of Lion’s Mane Mushrooms (hericium erinaceus). It’s kind of rare to find them fresh at a farmer’s market to eat raw, but you can also get them in a supplement form.

Definitely the cooler cousin in the fungi family (move over button and shitake), lion’s mane mushrooms (hericium erinaceus for the scientific set) have a long history in traditional Chinese medicine and in Native American healing practices. And because of the impressive benefits they may have to offer the mind and body, lion’s mane mushrooms have become increasingly popular.

“People are looking for alternatives for things before they go on medications,” says registered dietitian Beth Czerwony, RD, LD. “It’s in this holistic attitude that we find food is medicine.”

If you cannot find fresh Lion’s Mane to eat as a whole food, we suggest making sure the supplement you choose is from a brand you trust and made with 100% fully mature mushrooms, not quickly and cheaply grown mycelium on grain or other substrate. Some brands hide this cheaper method by using an image of the mature mushroom on their label while the ingredients clearly state the product you are consuming is powdered “mycelium” encapsulated with the growing substrates “rice” or “grain.”

Here are the highlighted health benefits of Lion’s Mane mushrooms from the article:

  1. Help support brain health
  2. Reduce inflammation and oxidative stress
  3. Protect your gut
  4. Support heart health
  5. Help fight cancer

Get 20% off all mushroom dual extracts December 24-27!

MERRY CHRISTMAS: Get an automatic 20% off all online orders for Half Hill Farm’s® mushroom dual extracts December 24 – December 27!

This surprise seasonal sale is an automatic discount and will apply to all online orders of our mushroom dual extracts on Half Hill Farm’s website only (does not include Amazon). All orders ship within 24 hours (except for weekends and holidays), and all orders over $150 ship for FREE!

The all-natural power of Turkey Tail Mushrooms!

TURKEY TAIL MUSHROOMS: (Trametes versicolor – pictured here growing at Half Hill Farm® in Woodbury, TN) have been used for centuries for better health & well-being with modern science validating its substantial health benefits.

Immunity – Turkey Tail mushrooms are used mostly for its immune-boosting polysaccharides (polysaccharide K and polysaccharide peptide) that enhance the immune functions of white blood cells. Polysaccharide K improves survival rates of patients with certain types of cancer when used as an adjunct therapy by inhibiting the growth of cancer cells and enhancing the body’s ability to fight cancer.

Gut-Health – The natural prebiotics found in turkey tail mushrooms help nourish beneficial bacteria in the gut for a stronger immune system and better digestion.

Inflammation – Turkey Tail mushrooms are also rich in antioxidants, which reduce inflammation and oxidative stress. This helps prevent damage to cells which lowers the risk of chronic diseases while promoting longevity.

You can take fully mature Turkey Tail mushrooms as an encapsulated powder. You can also decoct it into a tea or liquid dual extract which removes the indigestible chitinous biomass.

GIVING THANKS: 25% off mushroom dual extracts

Half Hill Farm Mushroom Dual Extracts

THANK YOU: We are so grateful to be your trusted source for better health & well being for the past 12 years. This Thanksgiving, we’re giving you 25% off all online and in store purchases of Half Hill Farm’s mushroom dual extracts!

This annual sale is an automatic discount and will apply to all online orders of Half Hill Farm’s mushroom dual extracts on our website and retail store (Wellness Emporium) between Monday November 25 and Monday December 2 only. All orders ship within 24 hours (except for weekends and holidays), and all orders over $150 ship for FREE!

Most major mushroom supplement makers use grain-cultivated mycelium grown in just a few days while depicting the mature mushrooms on their labels and marketing. Half Hill Farm has always used fully mature, certified organic and responsibly wildcrafted mushrooms that take months to grow and more than a month to extract.

Mushrooms are the oldest living organism on Earth and have evolved to survive every imaginable condition. Tap into the wisdom and longevity of fully mature mushrooms!

FALL SALE: 20% off all mushroom extracts October 1-15!

FALL SALE: get an automatic 20% off your mushroom extract purchases October 1-15, 2024! Mushrooms have been used for centuries for better health & well being and have evolved over eons of time and every imaginable condition to produce unique fungal compounds.

Tap into the wisdom of the ages with Half Hill Farm’s Turkey Tail, Lion’s Mane, Chaga, Red Reishi, Cordyceps, and Five Blend mushroom dual extracts. Our mushroom dual extracts come in 3.38oz and 6.76oz glass bottles. We only use fully mature organic and responsibly wildcrafted mushrooms for a quality our customers have come to love for a decade.

This 20% discount is valid October 1-15, 2024 on our store website and in our retail store in Woodbury, TN USA: Wellness Emporium.

All orders through our online store over $150 get automatic free USPS Priority shipping. All orders ship within 24 hours except weekends and holidays. If you’ve purchased our mushroom dual extracts before, click here to leave a review on Google. Thank you!

Get 20% off our mushroom dual extracts throughout September!

Celebrate the enduring power of mushrooms with 20% off your mushroom extract purchases throughout the month of September! Mushrooms have been used for centuries for better health & well being. As one of the planet’s oldest living things, mushrooms have evolved over eons of time and every imaginable condition to produce unique fungal compounds.

Tap into the wisdom of the ages with Half Hill Farm’s Turkey Tail, Lion’s Mane, Chaga, Red Reishi, Cordyceps, and Five Blend mushroom dual extracts. Our mushroom dual extracts come in 3.38oz and 6.76oz glass bottles. We only use fully mature organic and responsibly wildcrafted mushrooms for a quality our customers have come to love for a decade.

Take 20% off your purchase of our mushroom dual extracts using coupon code MUSHROOM20 at checkout. Offer valid September 1 – September 30, 2023.

All orders over $150 get automatic free USPS Priority shipping. All orders ship within 24 hours except weekends and holidays. We are forever grateful and humbled by your love and support over the past ten years. If you’ve purchased our mushroom dual extracts before, click here to leave a review on Google. Thank you!

We support accurate labeling of mushroom products

Two major mushroom product makers are at odds over what can be labeled as real mushroom products, and we have thoughts. NAMMEX wants the FDA to regulate the word “mushroom” in products to mean the full mature mushrooms depicted on their labels and in centuries of cultural use. Host Defense’s Paul Stamets wants his lab-grown mycelium to be labeled as the fully grown mushrooms depicted on his labels. As a mushroom extract maker who uses fully grown mature mushrooms, Half Hill Farm supports accurate labeling of mushroom products.

Recently, mushroom product maker NAMMEX filed a regulatory request with the FDA seeking clarity in mushroom supplements industry labeling.

At issue are major brands that make “mushroom” products from lab-grown sheets of mycelium cheaply propagated in a matter of days on rice or grain substrate. Once the substrate is myceliated, it is then dried, and extracted or encapsulated and labeled as made from the mature mushrooms often depicted on the label. These products unfortunately often contain the actual grain substrate in the product and are consumed by the purchaser. Some companies, like Host Defense, accurately include “rice” or “grain” in their ingredients because of this. Some don’t. Either way, the shorter and cheaper process certainly makes for more profit.

It is no surprise that some brands that make products from mycelium are upset with NAMMEX and have issued a statement opposing their effort. One statement, led by Host Defense’s Paul Stamets, argues that his company and other major brands should be able to label their mycelium products as “mushrooms” because mushrooms are made of the mycelium he uses to create his products. You can read his statement here.

At the same time this regulatory request for clarity is being made by a mushroom product maker, the poultry industry, in a bit of irony, won FDA approval allowing them to label lab-grown cultured cells as “chicken.” While science can definitively conclude a petri dish of cultured cells is indeed cultured from real chicken (just as mycologists can determine mycelium is cultured from real mushrooms), a plate of lab-grown cells is not the same as the real thing.

Here at Half Hill Farm, our mushroom extracts use the fully mature mushrooms pictured on our labels that take months to cultivate. Mature mushrooms experience months of growth and controlled conditions to produce the full spectrum of compounds that are extracted. The distinction between mushroom extracts and mycelium extracts set us apart from many major brands and is important to us.

Mushrooms have evolved to survive millions of years of changing conditions to be the oldest living thing on our planet. The result of that evolutionary outcome is eons of wisdom in the form of the full fruited body of the mushroom itself that we should respect and revere with proper labeling.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Take 15% off your purchase of our mushroom dual extracts using coupon code 4PACK at checkout when you purchase four or more 200ml bottles in any combination.

All orders over $150 get automatic free shipping. All orders ship within 24 hours except weekends and holidays.

Get 15% off our Turkey Tail Mushroom Dual Extract


TURKEY TAIL MUSHROOMS: Get 15% off when you buy four or more 200ml bottles of our mushroom dual extracts in any combination using code “4PACK” at https://store.halfhillfarm.com - all orders over $150 ship for FREE.

We’ve been making and using our mushroom dual extracts for over 10 years. Our mushroom dual extracts are made with all organic and responsibly wildcrafted ingredients in several stages through a 45 day extraction process. We only use the full fruited mushroom body in our extracts.

Mushrooms have been used for centuries for wellness and evolved through every imaginable condition to become one of the oldest life forms on the planet. Tap into the wisdom of the ages with our Turkey Tail, Lion’s Mane, Chaga, Red Reishi, Cordyceps, and Five Blend mushroom dual extracts.

Lion’s Mane mushroom extract improves brain cell growth

A new study in the January 2023 Journal of Neurochemistry shows unique compounds in Lion’s Mane mushroom extract boost memory by boosting nerve growth.

The study identified two bioactive compounds, N-de phenylethyl isohericerin and Hericene A, that appear to regulate the growth of neurons that improve memory.

The extracts had a “clear neurotrophic effect,” they write, resulting in doubly long axons – the threadlike links that conduct impulses away from a neuron – and more than triple the number of neurites, or small projections from a neuron that can grow into fully functional axons or dendrites.

“Laboratory tests measured the neurotrophic effects of compounds isolated from Hericium erinaceus on cultured brain cells, and surprisingly we found that the active compounds promote neuron projections, extending and connecting to other neurons,” Meunier says.

Researchers describe the compounds present in Lion’s Mane mushrooms as potent memory enhancers that may provide hope for natural memory enhancement for an aging population. Read more from University of Queensland researchers.