Chaga mushroom extract suppresses oral cancer

Chaga mushrooms (Inonotus obliquus) have been widely studied for their anti-tumor effects on many types of cancers (lung, liver, breast, colorectal). A recent study confirms Chaga mushroom extracts suppress oral cancer as well.

The study, supported by the National Research Foundation, suggests Chaga mushroom extracts are a promising natural supplement for the treatment of oral cancer. While the exact mechanism requires more research, the study indicates Chaga mushroom extract slows oral cancer cell growth by suppressing the cancer cell’s energy metabolism.

Several studies have shown the antitumor effects of Chaga mushrooms against various cancers, including lung adenocarcinoma, breast cancer, liver carcinoma, and colorectal cancer6,7,10,31. Chaga mushroom extract inhibits the growth of breast cancer cells by inducing autophagy processes6. Chaga mushroom constituents exhibit cytotoxic and proapoptotic activities in human lung cancer cells7. In addition, Chaga mushroom-derived ergosterol peroxide suppresses proliferation of colorectal cancer cells through down-regulation of β-catenin signaling10. Similarly, we demonstrated that Chaga mushroom extract decreases the proliferation of oral cancer cells by modulating cancer energy metabolism and autophagy. Furthermore, we have shown the anti-tumor effect of this extract in oral cancer cells through regulation of several cell signal pathways, including AMPK, STAT3, p38 MAPK, and NF-κB. This study, for the first time, found that Chaga mushroom extract suppresses oral cancer cell progression by inhibiting glycolysis and mitochondrial membrane potential.

Mature mushrooms vs mycelium: A 2024 up-dated summary of scientific findings outlines Chaga’s notable anticancer, antioxidant, anti-diabetic, anti-inflammatory, antimicrobial, and immunomodulating properties. The summary suggests extracted compounds from fully mature Chaga mushrooms have more direct impact on cancer than compounds from Chaga mycelium.

While polysaccharides from Chaga mycelium work by triggering the immune system, those from Chaga sclerotium directly block protein synthesis in malignant cells. These extracts and extracted compounds have shown to be non-toxic and have been used as possible cancer-preventive and chemotherapy substitutes. Endopolysaccharides from the mycelium operate indirectly by stimulating the immune system, whereas heteropolysaccharides and homoglucans from the sterile conk have direct anticancer effects [92].

How to consume: Chaga mushrooms don’t look like most mushrooms. Mature Chaga mushrooms are sclerotium fungi that infect birch trees in a symbiotic relationship that forms large woody conks. While you can consume these with some effort, the best way to tap into Chaga mushroom’s nutritive and medicinal value is to use an extract like those used in scientific studies.

The health benefits of honey bee propolis extract


Half Hill Farm’s Propolis Extract – available in 1 oz dropper bottles.

A couple years ago, I noticed honey bees actively coming and going from my compost bin. I thought I had unintentionally adopted a swarm. At any given moment there were about 25-50 bees coming and going. When I carefully opened the top, bees were all over the mushrooms we use to make our extracts. I didn’t know what to make of it so I started research that eventually led me to creating a new extract.

After reading about different roles of bees in the hive, I think these bees were tasked with gathering plant and tree resins that are collectively blended with enzymes and wax to form an amazing substance called propolis.

What is propolis: Bees use propolis as a structural glue and as a varnish protecting the hive from fungal, viral, bacterial infection and disease as well as invading small animals or small insects or mites. Propolis is loaded with vitamins and minerals, but propolis also includes polysaccharides that are also present in wood rotting fungi, including Turkey Tail mushrooms. The more I read the more I liked and began formulating a propolis extract for daily use.

Do bees use mushrooms: A few months later, self-taught mycologist Paul Stamets reported noticing bees on the ground sucking mycelium. Stamets believes his patented use of fungus may be a way to save honey bees from mites. But both of our observations might suggest bees are a step ahead of us and already use a broader range of the forest, including mushrooms and fungi, to protect the hive with blends of propolis.

It already happens with other bees. Last year, the Brazilian Agricultural Research Corporation discovered that the Brazilian stingless bee uses fungus in their propolis to protect larvae food stores from spoiling.

He and his team discovered that the fungus is a key part of the hive. It permeates the cerumen, a material made of wax and resin that the bees use as building material. After the bees have deposited regurgitated food for the larvae inside the cells, and laid an egg, the fungus starts growing.

Once the egg hatches, the larva feeds on the fungus, and it turns out this food is absolutely crucial. When the team tried to grow the bees in the lab without the fungus, the survival rate of the larvae dropped dramatically – from 72 per cent to just 8 per cent.

Mindful observation of nature can reveal tested paths toward better health and well-being. Bees and fungi have evolved to withstand thousands of centuries of environmental changes. While they may be no match for the destruction humans can cause to the environment, their survival and centuries of use by humans suggests honey bee propolis is one of those tested paths we must understand and protect.

Purchase propolis extract: Each 1 oz (30 ml) bottle of Half Hill Farm’s Propolis Extract contains roughly a three month supply with daily use and has a dropper for oral or topical application. Take 3-5 drops a day, or apply to minor cuts to create a liquid band-aid.

The health benefits of propolis: There have been many studies of propolis and its known uses dating back to 300 BC. Here is an excellent summary of propolis studies published in 2015 making the case for potential future drug development. Here is another summary of propolis studies from 2013 also pointing to many reasons why we make our propolis extract.

  • Composition: Raw propolis is 50% resins, 30% waxes, 10% essential oils, 5% pollen, and 5% organic compounds. Propolis contains calcium, iodine, potassium, sodium, manganese, magnesium, iron copper and zinc as well as vitamins B1, B2, B6, C, D and E.
  • Antioxident: High concentrations of flavinoids and phenolic acids in propolis reduce oxidative stress to proteins, lipids, nucleic acids and other biomolecules in the body. Oxidative stresses cause cells to die leading to a variety of diseases like cancer, diabetes and heart diseases.
  • Anti-inflammatory: When reactive oxygen species like hydrogen peroxide (H2O2) are not flushed from cells, inflammation occurs. Unresolved chronic inflammation can lead to many diseases like atherosclerosis, Alzheimer’s, Parkinson, asthma and cancer. Many studies show the flavinoids and cinnamic acid derivatives in propolis reduce inflammatory responses.
  • Antiviral: Studies show flavinoid rich propolis interferes with the RNA synthesis of herpes simplex 1 and 2, influenza, H1N1, HIV and other viruses.
  • Antibacterial, Antimicrobial: Propolis is effective against Gram-positive bacteria like Streptococcus mutans, which causes tooth decay and heart disease, Lactobacilli, and Staphylococcus.
  • Antifungal: Propolis is active against dermatophytes and yeasts, including several Candida strains – some resistant to known antifungal agents.
  • Antiprotozoal: Propolis shows activity against parasites that cause many diseases in humans. Studies show propolis is active against trichomoniasis, toxoplasmosis, giardiasis, Chagas disease, leishmaniasis, Giardia lamblia, Trichomonas vaginalis, Toxoplasma gondii, Leishmania donovani, Trypanosoma cruzi, and malaria.
  • Antitumor: Propolis acts against cancer cells by blocking oncogene signalling pathways, decreasing cancer proliferation by decreasing cancer stem cell populations and increasing cancer apoptosis. Propolis is active against colorectal, human breast, human tongue squamous cell carcinoma, and human prostate cancer cells. Studies show flavonoids from propolis could play a protective role against the toxicity of the chemotherapeutic agents or radiation therapy.
Please consult your physician before using any of our products for health purposes. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.